/* KFERQ finder. Colour is reserved for motif classes; everything else is ink on paper. */
:root {
  color-scheme: light;
  --paper: #ffffff;
  --ink: #1a1c23;
  --ink-2: #4a4e5c;
  --muted: #696d7c;
  --rule: #dfe1e6;
  --wash: #f3f4f6;
  --bar: #8b8f9c;
  --warn: #8a5a00;

  /* motif classes: validated as a set for colour-vision deficiency (secondary encoding: class codes) */
  --c-C: #eda100;
  --c-P: #2a78d6;
  --c-K: #008300;
  --c-KP: #1baf7a;
  --c-N: #e34948;
  --c-NP: #4a3aa7;

  --font: "Atkinson Hyperlegible Next", system-ui, -apple-system, "Segoe UI", sans-serif;
  --mono: "Atkinson Hyperlegible Mono", ui-monospace, "SF Mono", Menlo, monospace;
  --radius: 6px;
}

* { box-sizing: border-box; }
html { -webkit-text-size-adjust: 100%; }
body {
  margin: 0;
  background: var(--paper);
  color: var(--ink);
  font: 16px/1.5 var(--font);
}
a { color: inherit; text-underline-offset: 0.18em; }
a:hover { text-decoration-thickness: 2px; }
:focus-visible { outline: 2px solid var(--ink); outline-offset: 2px; }
[hidden] { display: none !important; }
.visually-hidden { position: absolute; width: 1px; height: 1px; overflow: hidden; clip: rect(0 0 0 0); white-space: nowrap; }

.wrap { max-width: 1080px; margin: 0 auto; padding: 0 16px; }

/* masthead: the logo and the name read as one unit; the description fills the line beside it */
.masthead { border-bottom: 1px solid var(--rule); padding: 22px 0 20px; margin-bottom: 24px; }
.masthead-grid {
  display: grid; align-items: center; column-gap: 28px; row-gap: 6px;
  grid-template-columns: auto 1fr auto;
  grid-template-areas: "logo title nav" "logo desc nav";
}
.logo { grid-area: logo; }
.logo img { display: block; height: 150px; width: auto; }
.site-title { grid-area: title; align-self: end; margin: 0; font-size: 44px; line-height: 1.05; font-weight: 700; letter-spacing: -0.01em; }
.site-title a { text-decoration: none; }
.site-desc { grid-area: desc; align-self: start; margin: 0; font-size: 17px; line-height: 1.45; color: var(--ink-2); max-width: 60ch; }
.masthead nav { grid-area: nav; align-self: start; display: flex; gap: 20px; font-size: 15px; }
.masthead nav a { text-decoration: none; color: var(--ink-2); padding: 4px 0; }
.masthead nav a[aria-current="page"] { color: var(--ink); box-shadow: inset 0 -2px 0 var(--ink); }
@media (max-width: 760px) {
  .masthead-grid { grid-template-columns: auto 1fr; grid-template-areas: "logo title" "logo nav" "desc desc"; column-gap: 16px; row-gap: 8px; }
  .logo img { height: 92px; }
  .site-title { font-size: 32px; }
  .masthead nav { align-self: start; }
  .site-desc { margin-top: 6px; font-size: 16px; }
}


/* tabs */
.tabs { display: flex; gap: 28px; border-bottom: 1px solid var(--rule); margin-bottom: 20px; overflow-x: auto; }
.tabs button {
  appearance: none; border: 0; background: none; cursor: pointer;
  font: 600 17px/1 var(--font); color: var(--ink-2);
  padding: 12px 0 13px; margin-bottom: -1px; border-bottom: 3px solid transparent; white-space: nowrap;
}
.tabs button[aria-selected="true"] { color: var(--ink); border-bottom-color: var(--ink); }
.tabs button:hover { color: var(--ink); }

/* motif class chips double as the colour legend */
.classes { border: 0; padding: 0; margin: 0 0 24px; }
.classes legend { font-weight: 600; font-size: 15px; padding: 0; margin-bottom: 8px; }
.class-chips { display: flex; flex-wrap: wrap; gap: 8px; margin-bottom: 10px; }
.class-chip {
  display: inline-flex; align-items: center; gap: 8px; cursor: pointer;
  border: 1px solid var(--rule); border-radius: 999px; padding: 5px 12px 5px 10px; font-size: 15px;
  color: var(--muted); user-select: none;
}
.class-chip { position: relative; }
.class-chip input { position: absolute; opacity: 0; pointer-events: none; }
.class-chip .dot { width: 12px; height: 12px; border-radius: 50%; border: 2px solid var(--c); background: transparent; }
.class-chip .code { font: 600 12px/1 var(--font); color: var(--muted); }
.class-chip:has(input:checked) { color: var(--ink); border-color: var(--ink-2); }
.class-chip:has(input:checked) .dot { background: var(--c); }
.class-chip:has(input:focus-visible) { outline: 2px solid var(--ink); outline-offset: 2px; }
.class-chip.advanced { border-style: dashed; }

.toggle { display: flex; gap: 8px; align-items: baseline; font-size: 15px; color: var(--ink-2); margin: 6px 0; }
.toggle input { margin: 0; transform: translateY(2px); }

/* forms */
.panel { padding-bottom: 32px; }
.field-label { display: block; font-weight: 600; font-size: 15px; margin: 0 0 2px; }
.hint { margin: 0 0 8px; font-size: 14px; color: var(--muted); max-width: 72ch; }
.field-row { display: flex; flex-wrap: wrap; align-items: end; gap: 12px 20px; margin-bottom: 16px; }
.field-row .hint { margin: 0 0 6px; flex: 1 1 280px; }
.coverage.low { color: var(--warn); }
textarea, select, input[type="number"] {
  font: 15px/1.45 var(--font); color: var(--ink); background: var(--paper);
  border: 1px solid #c9ccd4; border-radius: var(--radius); padding: 8px 10px;
}
textarea { display: block; width: 100%; font-family: var(--mono); font-size: 14px; padding: 12px; resize: vertical; }
textarea:disabled { background: var(--wash); color: var(--muted); }
select { padding-right: 28px; min-width: 200px; }
input[type="number"] { width: 110px; }
textarea:focus-visible, select:focus-visible, input:focus-visible { outline: 2px solid var(--ink); outline-offset: 1px; }

.actions { display: flex; flex-wrap: wrap; gap: 10px; align-items: center; margin: 14px 0 0; }
.btn {
  display: inline-flex; align-items: center; justify-content: center; cursor: pointer;
  font: 600 15px/1 var(--font); color: var(--ink); text-decoration: none;
  background: var(--paper); border: 1px solid #c9ccd4; border-radius: var(--radius); padding: 11px 16px;
}
.btn:hover { border-color: var(--ink-2); }
.btn.primary { background: var(--ink); border-color: var(--ink); color: var(--paper); }
.btn.primary:hover { background: #343744; }
.btn.quiet { border-color: transparent; text-decoration: underline; text-underline-offset: 0.2em; padding-inline: 8px; }
.btn.small { padding: 8px 12px; font-size: 14px; margin-top: 8px; }
.btn[disabled], .btn[aria-disabled="true"] { opacity: 0.45; cursor: not-allowed; }
.btn:has(input:focus-visible) { outline: 2px solid var(--ink); outline-offset: 2px; }

.two-col { display: grid; gap: 20px 32px; grid-template-columns: 1fr; }
@media (min-width: 760px) { .two-col { grid-template-columns: 1fr 1fr; } }
.bg-choice { border: 0; padding: 0; margin: 0 0 8px; }
.bg-choice label { display: flex; gap: 8px; align-items: baseline; font-size: 15px; margin: 4px 0; }
.settings { margin: 16px 0 0; }
.settings summary { cursor: pointer; font-weight: 600; font-size: 15px; color: var(--ink-2); }
.settings .field-row { margin: 12px 0 0; }

/* results */
.results:empty { display: none; }
.results { margin-top: 28px; border-top: 1px solid var(--rule); padding-top: 20px; }
.summary { font-size: 18px; margin: 0 0 6px; max-width: 72ch; }
.notes { margin: 0 0 12px; padding: 0; list-style: none; font-size: 14px; color: var(--ink-2); }
.notes li { margin: 2px 0; }
.notes .warn { color: var(--warn); }
.status { font-size: 15px; color: var(--ink-2); }
.error { color: #b3261e; font-weight: 600; }

table { border-collapse: collapse; width: 100%; font-size: 15px; font-variant-numeric: tabular-nums; }
th { text-align: left; font-size: 13px; font-weight: 600; color: var(--ink-2); padding: 8px 12px 8px 0; border-bottom: 1px solid var(--ink-2); }
td { padding: 10px 12px 10px 0; border-bottom: 1px solid var(--rule); vertical-align: top; }
td.num, th.num { text-align: right; }
.table-scroll { overflow-x: auto; }
.protein-name { font-weight: 600; }
.protein-meta { font-size: 13px; color: var(--muted); }
.protein-meta a { color: var(--ink-2); }
.badge { display: inline-block; font-size: 12px; color: var(--ink-2); border: 1px solid var(--rule); border-radius: 4px; padding: 0 5px; margin-left: 4px; }
.none { color: var(--muted); font-size: 14px; }

.motifs { display: flex; flex-wrap: wrap; gap: 6px; }
.motif {
  display: inline-flex; align-items: center; gap: 6px;
  border: 1px solid var(--rule); border-radius: 999px; padding: 2px 9px 2px 7px;
  font-size: 13px; white-space: nowrap;
}
.motif .dot { width: 9px; height: 9px; border-radius: 50%; background: var(--c); }
.motif .seq { font: 600 13px/1.3 var(--mono); letter-spacing: 0.03em; }
.motif .pos, .motif .code { color: var(--muted); }
.motif .ub { font-size: 11px; font-weight: 700; color: var(--ink-2); border-left: 1px solid var(--rule); padding-left: 6px; }

.linkish { appearance: none; background: none; border: 0; padding: 0; font: inherit; font-size: 14px; color: var(--ink-2); text-decoration: underline; text-underline-offset: 0.2em; cursor: pointer; white-space: nowrap; }
.seq-row td { background: #fafafb; padding: 14px 16px; }

/* highlighted sequence view */
.seqview { font: 15px/2.5 var(--mono); overflow-x: auto; white-space: pre; padding-top: 4px; }
.seqview .line { display: block; }
.seqview .pos { display: inline-block; width: 6ch; text-align: right; margin-right: 2ch; color: var(--muted); font-size: 13px; }
.seqview .gap { margin-right: 1ch; }
mark.m { color: inherit; background: color-mix(in srgb, var(--c) 26%, white); box-shadow: inset 0 -3px 0 var(--c); padding: 0; }
.start { position: relative; }
.start::before {
  content: attr(data-code); position: absolute; left: 0; top: -1.15em;
  font: 600 10px/1 var(--font); color: var(--ink-2); letter-spacing: 0;
}
.seq-legend { font-size: 13px; color: var(--muted); margin: 6px 0 0; }

.m-C { --c: var(--c-C); }
.m-P { --c: var(--c-P); }
.m-K { --c: var(--c-K); }
.m-KP { --c: var(--c-KP); }
.m-N { --c: var(--c-N); }
.m-NP { --c: var(--c-NP); }

/* summary by class */
.rank-choice { display: flex; flex-wrap: wrap; gap: 4px 18px; align-items: baseline; font-size: 15px; color: var(--ink-2); margin: 8px 0 0; }
.rank-choice label { display: inline-flex; gap: 6px; align-items: baseline; }
.view-switch { display: inline-flex; border: 1px solid #c9ccd4; border-radius: var(--radius); overflow: hidden; margin: 8px 0 16px; }
.view-switch button { appearance: none; border: 0; background: var(--paper); font: 600 14px/1 var(--font); color: var(--ink-2); padding: 10px 14px; cursor: pointer; }
.view-switch button + button { border-left: 1px solid #c9ccd4; }
.view-switch button[aria-pressed="true"] { background: var(--ink); color: var(--paper); }
.fig-controls { display: flex; flex-wrap: wrap; gap: 8px 32px; margin: 4px 0 14px; font-size: 14px; }
.fig-controls [role="radiogroup"] { display: flex; flex-wrap: wrap; gap: 4px 16px; align-items: baseline; }
.fig-controls label { display: inline-flex; gap: 6px; align-items: baseline; }
.ctl-label { font-weight: 600; color: var(--ink); }
.summary-fig { margin: 0 0 8px; }
.summary-fig svg { display: block; width: 100%; height: auto; }
.combo-table { max-width: 720px; }
.combo-dots { display: inline-flex; gap: 5px; vertical-align: -1px; }
.combo-dots i { width: 11px; height: 11px; border-radius: 50%; background: #e4e5ea; }
.combo-dots i.on { background: var(--c); }
.share { color: var(--muted); }
.yes { display: inline-flex; align-items: center; gap: 6px; }
.yes i { width: 10px; height: 10px; border-radius: 50%; background: var(--c); }
.no { color: #8d909c; }

/* enrichment */
.headline { font-size: 22px; line-height: 1.35; margin: 0 0 8px; max-width: 60ch; }
.verdict { font-size: 16px; margin: 0 0 16px; max-width: 72ch; }
.compare { max-width: 720px; margin: 8px 0 20px; }
.compare th:not(:first-child), .compare td:not(:first-child) { text-align: right; }
.charts { display: grid; gap: 24px 32px; grid-template-columns: 1fr; margin: 8px 0 20px; }
@media (min-width: 760px) { .charts { grid-template-columns: 1fr 1fr; } }
.chart h4 { margin: 0 0 2px; font-size: 15px; }
.chart p { margin: 0 0 6px; font-size: 13px; color: var(--muted); }
.chart svg { display: block; width: 100%; height: auto; overflow: visible; }
.chart .axis text { font: 14px var(--font); fill: var(--muted); }
.chart .axis line { stroke: #c3c5cc; }
.chart .bar { fill: var(--bar); }
.chart .hit:hover + .bar, .chart .bar.active { fill: var(--ink-2); }
.chart .obs line { stroke: var(--ink); stroke-width: 2; }
.chart .obs text { font: 600 14px var(--font); fill: var(--ink); }
.facts { display: grid; grid-template-columns: max-content 1fr; gap: 4px 20px; font-size: 14px; margin: 0 0 20px; }
.facts dt { color: var(--muted); }
.facts dd { margin: 0; }
h3.section { font-size: 16px; margin: 24px 0 6px; }

.tooltip {
  position: fixed; z-index: 10; pointer-events: none;
  background: var(--ink); color: var(--paper); font-size: 13px; padding: 6px 9px; border-radius: 4px;
  max-width: 260px;
}

/* about page */
.prose { max-width: 72ch; padding-bottom: 24px; }
.prose h1 { font-size: 30px; line-height: 1.2; margin: 0 0 12px; }
.prose h2 { font-size: 20px; margin: 32px 0 8px; }
.prose li { margin: 4px 0; }
.prose table { margin: 12px 0; }
.swatch { display: inline-block; width: 11px; height: 11px; border-radius: 50%; background: var(--c); margin-right: 6px; vertical-align: -1px; }

.site-footer { border-top: 1px solid var(--rule); margin-top: 24px; padding-top: 16px; padding-bottom: 32px; font-size: 13px; color: var(--muted); }
.site-footer p { margin: 0 0 6px; max-width: 90ch; }

@media (max-width: 560px) {
  .tabs { gap: 20px; }
  .tabs button { font-size: 16px; }
}
@media (prefers-reduced-motion: reduce) { * { scroll-behavior: auto !important; } }